ParkinsonV1, Main, Exploration, bibRecord, 000067

Analysis of Gray Matter in AD Patients and MCI Subjects Based Voxel-Based Morphometry

Identifieur interne : 000067 ( Main/Exploration ); précédent : 000066; suivant : 000068

Analysis of Gray Matter in AD Patients and MCI Subjects Based Voxel-Based Morphometry

Auteurs : Zhijun Yao [République populaire de Chine] ; Bin Hu [République populaire de Chine, Royaume-Uni] ; Lina Zhao [République populaire de Chine] ; Chuanjiang Liang [République populaire de Chine]

Source :

Lecture Notes in Computer Science [ 0302-9743 ] ; 2011.

RBID : ISTEX:EB19AA18362F9BE83CEE8AB2A7B52EB3E9C51AE5

Abstract

Abstract: In recent years, pathological researches of mild cognitive impairment (MCI) subjects and the Alzheimer’s disease (AD) patients have gained a great deal of attention. In this study, we used the voxel-based morphometry (VBM) method to analyze the Magnatic Resonance Imaging (MRI) data of gray matter volumes in 98 normal controls (NCs), 91 AD patients and 113 MCI subjects. The measurements of gray matter volumes were calculated for each of the three groups respectively. We found that compared with MCI subjects, AD patients had further atrophy in the following brain regions: right insula, left hippocampus, right fusiform and bilateral middle temporal gyrus. Compared with NCs, AD patients and MCI subjects shared some abnormal brain regions such as bilateral parahippocampal gyrus, bilateral hippocampus, left amygdala and left fusiform. The results provided additional evidences to support the viewpoint that MCI is the transitional stage between normal aging and AD.

Url:

https://api.istex.fr/document/EB19AA18362F9BE83CEE8AB2A7B52EB3E9C51AE5/fulltext/pdf

DOI: 10.1007/978-3-642-23605-1_22

Affiliations:

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<front><div type="abstract" xml:lang="en">Abstract: In recent years, pathological researches of mild cognitive impairment (MCI) subjects and the Alzheimer’s disease (AD) patients have gained a great deal of attention. In this study, we used the voxel-based morphometry (VBM) method to analyze the Magnatic Resonance Imaging (MRI) data of gray matter volumes in 98 normal controls (NCs), 91 AD patients and 113 MCI subjects. The measurements of gray matter volumes were calculated for each of the three groups respectively. We found that compared with MCI subjects, AD patients had further atrophy in the following brain regions: right insula, left hippocampus, right fusiform and bilateral middle temporal gyrus. Compared with NCs, AD patients and MCI subjects shared some abnormal brain regions such as bilateral parahippocampal gyrus, bilateral hippocampus, left amygdala and left fusiform. The results provided additional evidences to support the viewpoint that MCI is the transitional stage between normal aging and AD.</div>
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Analysis of Gray Matter in AD Patients and MCI Subjects Based Voxel-Based Morphometry

Analysis of Gray Matter in AD Patients and MCI Subjects Based Voxel-Based Morphometry

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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